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Our Health Library information does not replace the advice of a doctor. Please be advised that this information is made available to assist our patients to learn more about their health. Our providers may not see and/or treat all topics found herein.

Rh sensitization

Rh sensitization happens if you have Rh-negative blood and are exposed to Rh-positive blood. Because the blood types don't match, you can develop antibodies against the Rh-positive blood. If you are pregnant, you can become sensitized if your baby has Rh-positive blood. Exposure to your baby's blood happens most often during delivery. This often isn't a problem in the first pregnancy. But if you get pregnant again with an Rh-positive baby, antibodies in your blood can attack the baby's blood cells and cause serious problems.

A blood test is the only way to know you have Rh sensitization or are at risk for it.

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